By Richard V Heinzelman; American Chemical Society. Division of Medicinal Chemistry
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Additional resources for Annual reports in medicinal chemistry. / Volume 7
A. Welle, J. van DGk, J. E. Davies, V. Claassen and T. A. C. Boschman, Chim. , 5, 367 (1970). 37. M. N. Aboul-hein, L. Morgan and J. Sam, J. Pharm. , 61, 127 (1972). 18. D. Lhstead and D. Wilkie, Biochem. , El 839 6 7 1 ) . 39. B. Cubinsky, K. Karpowicz and M. E. Goldberg, Pharmacologist, 2,255 (1971). 40. C. Barchewitz and H. , 2, 293 (1970). 41. G. Salomon, R. Wolf and A. Ma%re, Gaz. k d . France 78, 1040 (1971). Curr. Ther. , C l h . , l4, 61 (1972). 42. D. M. Gallant, M. P. Bishop and R. Guerrer-Figueroa, 43.
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The sustained wakefulness of animals treated with PCPA may feasibly be considered one manifestation of this generalized hyperresponsiveness. The animal behavioral data from PCPA, taken as a whole, may be loosely interpreted as suggesting that 5-HT subserves behavioral inhibitory functions, and that a relative absence of 5-HT produces hypersensitivity to environmental cues. Both the rapid reversal of electrophysiological and behavioral changes following smalldoses of 5-HTP, and the parallel time course of PCPA actions with brain 5-HT levels clearly associate 5-HT with its effects.
Annual reports in medicinal chemistry. / Volume 7 by Richard V Heinzelman; American Chemical Society. Division of Medicinal Chemistry